Top+Ten+Things+to+Remember!!

=Ten Things to Remember!=


 * 1) ======Coronaviruses have the largest genomes of all the RNA viruses (27-31 kb)======
 * 2) ======Coronaviruses are unique in that they create nested genomic transcripts (Nidovirales)======
 * 3) ======Coronaviruses use ribosome frameshifting (in ORF1a/b to sythesize the polymerase)======
 * 4) ======Coronaviruses are pleomorphic: some are spherical (genus coronavirus) while others are disk-like (genus torovirus)======
 * 5) ======Coronaviruses are typically limited to one host species - except for SARS!======
 * 6) ======There are no vaccines for any of the Coronaviruses, but drugs can be used to provide symptomatic relief======
 * 7) ======Pathogenesis is localized to the epithelial cells of the respiratory or enteric tracts, but can spread to other epithelial cell types======
 * 8) ======Coronaviruses bear the characteristic peplomers projecting from the envelope, giving the virus a crown-like appearance======
 * 9) ======Coronaviruses are one of the main causes of the common cold (#2 after rhinoviruses)======
 * 10) ======While SARS was a terrifying outbreak and the subject of international concern, but the number of mortalities (372/5663) are dwarfed by the number of casualties produced by infantile diarrhea or malaria, HIV, and tuberculosis======

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